Lipid Based Formulations in Hard Gelatin and HPMC Capsules: a Physical Compatibility Study
| Autor: | Hans Coppenolle, Ingrid Djouka Tenekam, Sanket M. Shah, Nicolas Sauwen, Niklas J. Koehl, René Holm, Sien Vingerhoets, Tatsiana Khamiakova |
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| Rok vydání: | 2021 |
| Předmět: |
hard gelatin capsules
food.ingredient Materials science soft gel capsules Pharmaceutical Science Excipient Polyethylene glycol Miscibility Gelatin Polyvinyl alcohol chemistry.chemical_compound food lipid based formulation medicine HPMC capsules Pharmacology (medical) Pharmacology capsule compatibility Chromatography Organic Chemistry Capsule lipid excipients chemistry Compatibility (mechanics) SNEDDS Molecular Medicine liquid filled capsule Biotechnology Olive oil medicine.drug |
| Zdroj: | Koehl, N J, Shah, S, Tenekam, I D, Khamiakova, T, Sauwen, N, Vingerhoets, S, Coppenolle, H & Holm, R 2021, ' Lipid Based Formulations in Hard Gelatin and HPMC Capsules : a Physical Compatibility Study ', Pharmaceutical Research, vol. 38, no. 8, pp. 1439-1454 . https://doi.org/10.1007/s11095-021-03088-8 |
| ISSN: | 1573-904X 0724-8741 |
| Popis: | Purpose: To investigate the compatibility between hard gelatin and HPMC capsules with a range of different isotropic lipid based formulations containing multiple excipients. Methods: The miscibility was investigated for 350 systems applying five different oils (Labrafac ™ lipophile WL1349, Maisine® CC, Captex 300 EP/NF, olive oil, and Capmul MCM EP/NF), five different surfactans (Labrasol ® ALF, Labrafil M 2125 CS, Kolliphor ® ELP, Kolliphor ® HS 15, Tween 80) and three different cosolvents (propylene glycol, polyethylene glycol 400, and Transcutol ® HP). For the isotropic systems capsule compatibility was investigated in both gelatin and HPMC capsules at 25°C at 40% and 60% relative humidity by examining physical damages to the capsules and weight changes after storage. Results: The miscibility of lipid based vehicles was best when the formulation contained monoglycerides and surfactants with a hydrophilic–lipophilic balance value |
| Databáze: | OpenAIRE |
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