Polyethylene glycol (PEG-400) promoted one-pot, five-component synthesis of (E)-ethyl2-(2-((E)-2-(1-(4-methyl-2-(phenylamino)thiazol-5yl)ethylidene)hydrazinyl)-4-oxothiazol-5(4H)-ylidene)acetates
| Autor: | Rajeswar Rao Vedula, Kodam Sujatha |
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| Rok vydání: | 2019 |
| Předmět: |
Carboxylic Acids
Polyethylene glycol Acetates 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis Polyethylene Glycols Inorganic Chemistry chemistry.chemical_compound Cascade reaction Pentanes Drug Discovery Physical and Theoretical Chemistry Molecular Biology PEG 400 Aniline Compounds 010405 organic chemistry Component (thermodynamics) Organic Chemistry Green Chemistry Technology General Medicine Semicarbazides 0104 chemical sciences Solvent chemistry Solvents Thiocyanates Information Systems |
| Zdroj: | Molecular Diversity. 24:413-421 |
| ISSN: | 1573-501X 1381-1991 |
| DOI: | 10.1007/s11030-019-09962-3 |
| Popis: | A facile, inexpensive and eco-friendly synthesis of functionalised (E)-ethyl2-(2-((E)-2-(1-(4-methyl-2-(phenylamino)thiazol-5yl)ethylidene)hydrazinyl)14-oxothiazol-5(4H)-ylidene)acetates has been developed via one-pot five-component approach. The title compounds were synthesized by the reaction of anilines, 3-chloropentane-2,4-dione, ammoniumthiocyanate, thiosemicarbazide and dialkylacetylene dicarboxylate using polyethylene glycol as green and recyclable solvent. The domino reaction proceeded smoothly in good-to-excellent yields. |
| Databáze: | OpenAIRE |
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