Subcritical water hydrolysis of N-acetyl-D-glucosamine: Hydrolysis mechanism, reaction pathways and optimization for selective production of 5-HMF and levulinic acid

Autor: Sphurti Prakash Kulkarni, Shital N. Dure, Sunil S. Joshi, Kiran V. Pandare, Nilesh A. Mali
Rok vydání: 2021
Předmět:
Zdroj: Carbohydrate research. 516
ISSN: 1873-426X
Popis: In this study, the subcritical water hydrolysis of N-acetyl-d-glucosamine (NAG), a monomer of abundant renewable marine biopolymer chitin, for production of value-added chemicals is investigated. The enhanced ionization of water at subcritical conditions (200 °C; 50-100 bar), provides enough acidity for deacetylation of NAG resulting in 80% yield of acetic acid along with traces of formic acid, lactic acid, glucose, fructose, 5-hydroxymethylfurfural (5-HMF),etc. The significant humin formation indicates that the self-condensation and polymerisation of 5-HMF is favored in water at subcritical conditions. A catalyst p-toluenesulfonic acid (p-TsOH) was employed to selectively convert NAG to levulinic acid (LA) via ring opening of 5-HMF previously formed during hydrolysis. The maximum yield of 27.13 ± 1% and 53.46 ± 1% of 5-HMF and LA, respectively, was obtained at process conditions optimized using Box-Behnken design coupled with response surface methodology. Subcritical water enables greener conversion of NAG to platform chemicals wherein the selective production can be achieved by tuning the process conditions.
Databáze: OpenAIRE