Monitoring of Peripheral Blood CD34+ Cell Counts on the First Day of Apheresis Is Highly Predictive for Efficient CD34+ Cell Yield
| Autor: | Mutlu Arat, Suleyman Dincer, Muhit Ozcan, Hamdi Akan, Turgay Fen, Meltem Ayli, Akin Uysal, Gülsüm Özet, Erol Ayyildiz, Onder Arslan, Gunhan Gurman, Osman Ilhan, Taner Demirer, Yasemin Genç, Nahide Konuk, M. Dagli, Klara Dalva, Haluk Koç, Rauf Haznedar |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Adolescent Lymphoma Neutrophils Cd34 cells Antigens CD34 Peripheral blood mononuclear cell Andrology medicine Humans Platelet Leukapheresis Monitoring Physiologic Blood Specimen Collection Platelet Count business.industry Lymphoma Non-Hodgkin General Medicine Middle Aged medicine.disease Hodgkin Disease Peripheral blood Apheresis Yield (chemistry) Immunology Multiple Myeloma business |
| Zdroj: | Therapeutic Apheresis. 6:384-389 |
| ISSN: | 1526-0968 1091-6660 |
| DOI: | 10.1046/j.1526-0968.2002.00406.x |
| Popis: | The purpose of this study was to evaluate the correlation of preleukapheresis circulating CD34+ cells/muL, white blood cells (WBC), and platelet counts on the first day of apheresis with the yield of collected CD34+ cell counts in 40 patients with hematological malignancies (n = 29) and solid tumors (n = 11). The median numbers of apheresis cycles, numbers of CD34+ cells, peripheral blood (PB) mononuclear cells, and total nucleated cells collected were 2 (range, 1-4), 5.5 x 10(6) /kg (range, 0.05-33.78), 2.59 x 10(8)/kg (range, 0.04-20.68), and 7.36 x 10(8)/kg (range, 0.15-28.08), respectively. There was a strong correlation between the number of preleukapheresis circulating CD34+ cells/muL and the yield of collected CD34+ cells per kilogram (r = 0.962, p < 0.001). The threshold levels of PB CD34+ cell/muL to obtain greater than or equal to1 x 10(6)/kg and greater than or equal to2.5 x 10(6)/kg CD34+ cell in one collection were 12/muL and 34/muL, respectively. Fifteen of 17 (88%) patients who had greater than or equal to34 CD34+ cells/muL in the PB before collection reached the level of greater than or equal to2.5 x 10(6)/kg in a single apheresis. Despite a low r value, WBC and platelet counts on the first day of apheresis also correlated with the yield of collected daily CD34+ cells per kilogram (r = 0.482, p < 0.01 and r = 0.496 p < 0.01, respectively). These data suggest that preleukapheresis circulating CD34+ cells/muL correlated significantly better with the yield of collected CD34+ cells than WBC and platelet counts on the first day of apheresis. Using a value of 34/muL preleukapheresis circulating CD34+ cells as a guide for the timing of peripheral blood stem cells collections can be time saving and cost-effective. |
| Databáze: | OpenAIRE |
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