Strong influence of livestock environments on the emergence and dissemination of distinct multidrug-resistant phenotypes among the population of non-typhoidal Salmonella

Autor: Jeannette Munoz-Aguayo, Sahar Alshalchi, Sinisa Vidovic, Christian Flores-Figueroa, Ran An, Peter Breimhurst
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Serotype
Bacterial Diseases
Salmonella
Swine
Antibiotics
Cephalosporin
lcsh:Medicine
Drug resistance
medicine.disease_cause
Pathology and Laboratory Medicine
Medicine and Health Sciences
lcsh:Science
education.field_of_study
Multidisciplinary
Antimicrobials
Drugs
Agriculture
Drug Resistance
Multiple
Bacterial Pathogens
Anti-Bacterial Agents
Infectious Diseases
Salmonella Enterica
Tetracyclines
Medical Microbiology
Vertebrates
Salmonella Infections
Pathogens
Research Article
Fluoroquinolones
Livestock
medicine.drug_class
030106 microbiology
Population
Biology
Microbiology
Bacterial genetics
Birds
03 medical and health sciences
Enterobacteriaceae
Microbial Control
Drug Resistance
Bacterial
medicine
Animals
Humans
Serotyping
education
Microbial Pathogens
Pharmacology
Bacteria
business.industry
lcsh:R
Organisms
Biology and Life Sciences
Penicillin
Biotechnology
Cephalosporins
Multiple drug resistance
Amniotes
lcsh:Q
Cattle
Antimicrobial Resistance
business
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 6, p e0179005 (2017)
ISSN: 1932-6203
Popis: The problem of emergence and dissemination of multidrug resistance, especially among Gram-negative bacteria, has reached alarming levels. This increases the need to develop surveillance methods that more effectively and accurately provide information about the emergence and spread of multidrug-resistant organisms. In this study, using a well-defined population of non-typhoidal Salmonella (NTS) isolates associated with avian, bovine and porcine hosts, we found that the livestock environments had a specific (P < 0.005) and profound (P < 0.005) effect on the evolution of multidrug-resistant phenotypes among population of NTS isolates. The MDR pattern containing penicillins, tetracyclines and macrolides and the evolving counterparts (i.e., penicillins, tetracyclines and macrolides + other antibiotic classes) were significantly (P < 0.005) associated with NTS isolates of porcine origin. Similarly, MDR patterns containing folate pathway inhibitors, macrolides and aminocyclitol or containing penicillins, cephalosporins, tetracyclines, phenicols and macrolides were significantly associated with avian (P < 0.005) and bovine (P < 0.005) NTS isolates, respectively. Furthermore, STRUCTURE, an evolutionary analysis, clearly showed that the host origin (i.e., livestock environment), and not the genetic background of different NTS serovars, was the most determinative factor for acquisition and spread of MDR phenotypes. In addition, we described a novel non-synonymous mutation, located outside of the QRDR at position 864 of GyrA, that was likely associated with fluoroquinolone resistance.
Databáze: OpenAIRE
Externí odkaz: