Surgical and not analgesic technique affects postoperative inflammation following colorectal cancer surgery: a prospective, randomized study
| Autor: | Anita Sjölander, Pär Myrelid, Peter Matthiessen, Christina Eintrei, Wiebke Siekmann, Anders Magnuson, Anil Gupta |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Laparoscopic surgery
Adult Male Surgical stress Hydrocortisone Colorectal cancer medicine.medical_treatment Inflammation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030202 anesthesiology medicine Humans Insulin Pain Management Postoperative Period Prospective Studies Prospective cohort study Digestive System Surgical Procedures Aged Aged 80 and over Analgesics Pain Postoperative business.industry Gastroenterology Analgesia Patient-Controlled Perioperative Middle Aged medicine.disease Vascular endothelial growth factor Analgesia Epidural Treatment Outcome chemistry 030220 oncology & carcinogenesis Anesthesia Cytokines Administration Intravenous Female Laparoscopy medicine.symptom business Colorectal Neoplasms Abdominal surgery |
| Zdroj: | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 19(6) |
| ISSN: | 1463-1318 |
| Popis: | AIM: Epidural analgesia reduces the surgical stress response. However, its effect on pro- and anti-inflammatory cytokines in the genesis of inflammation following major abdominal surgery remains unclear. Our main objective was to elucidate whether perioperative epidural analgesia prevents the inflammatory response following colorectal cancer surgery.METHODS: Ninety-six patients scheduled for open or laparoscopic surgery were randomized to epidural analgesia (group E) or patient-controlled intravenous analgesia (group P). Surgery and anaesthesia were standardized in both groups. Plasma cortisol, insulin and serum cytokines [interleukin 1β (IL-1β), IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, tumour necrosis factor α, interferon γ, granulocyte-macrophage colony-stimulating factor, prostaglandin E2 and vascular endothelial growth factor] were measured preoperatively (T0), 1-6 h postoperatively (T1) and 3-5 days postoperatively (T2). Mixed model analysis was used, after logarithmic transformation when appropriate, for analyses of cytokines and stress markers.RESULTS: >There were no significant differences in any serum cytokine concentration between groups P and E at any time point except for IL-10 which was 87% higher in group P [median and range 4.1 (2.3-9.2) pg/ml] compared to group E [2.6 (1.3-4.7) pg/ml] (P = 0.002) at T1. There was no difference in plasma cortisol and insulin between the groups at any time point after surgery. A significant difference in median serum cytokine concentration was found between open and laparoscopic surgery with higher levels of IL-6, IL-8 and IL-10 at T1 in patients undergoing open surgery compared to laparoscopic surgery. No difference in serum cytokine concentration was detected between the groups or between the surgical technique at T2.CONCLUSIONS: Open surgery, compared to laparoscopic surgery, has greater impact on these inflammatory mediators than epidural analgesia vs intravenous analgesia. (Less) |
| Databáze: | OpenAIRE |
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