Pediatric Orofacial and Laryngopharyngeal Rhabdomyosarcoma: An Intergroup Rhabdomyosarcoma Study Report
| Autor: | Walter Lawrence, Ruth Heyn, Melvin Tefft, R. Beverly Raney, Moody D. Wharam, Frederick B. Ruymann, Harold M. Maurer, Mohan Beltangady, Edward H. Soule |
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| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Salvage therapy Random Allocation Rhabdomyosarcoma Biopsy medicine Humans Prospective Studies Child Prospective cohort study Laryngeal Neoplasms Survival rate Mouth neoplasm Chemotherapy medicine.diagnostic_test business.industry Infant Newborn Infant Pharyngeal Neoplasms General Medicine medicine.disease Combined Modality Therapy Surgery Radiation therapy Otorhinolaryngology Head and Neck Neoplasms Child Preschool Female Mouth Neoplasms Facial Neoplasms business |
| Zdroj: | Archives of Otolaryngology - Head and Neck Surgery. 113:1225-1227 |
| ISSN: | 0886-4470 |
| DOI: | 10.1001/archotol.1987.01860110091014 |
| Popis: | • Eighty-nine children with localized rhabdomyosarcoma of orofacial and laryngopharyngeal sites were treated in accordance with the first and second Intergroup Rhabdomyosarcoma Study (IRS) protocols (IRS-I and IRS-II) between 1972 and 1984. Treatment included surgery (or biopsy) and chemotherapy for all patients and radiotherapy in the majority. The actuarial estimate of the three-year survival rate for all patients was 83% and did not differ significantly by primary site, histologic findings, or presence of adenopathy. A trend for a worse survival rate was seen in clinical group III patients and in those less than 5 years of age at diagnosis. Factors associated with an increased risk of local/regional relapse included omission of radiotherapy and a radiation dose of less than 40 Gy (4000 rad). We conclude that treatment of these patients as recommended in the IRS-I and IRS-II protocols results in very good local and regional tumor control and survival rates. Salvage therapy for local/regional recurrence may yield long-term remission and possibly cure. ( Arch Otolaryngol Head Neck Surg 1987;113:1225-1227) |
| Databáze: | OpenAIRE |
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