Patterns of peritoneal dissemination and response to systemic chemotherapy in common and rare peritoneal tumours treated by cytoreductive surgery: study protocol of a prospective, multicentre, observational study
| Autor: | Daniel M. Labow, Nazim Benzerdjeb, Brendan Moran, Vadim Gushchin, Sanket Mehta, Aditi Bhatt, Almog Ben Yacov, Ignace H. J. T. de Hingh, Edward A. Levine, Laurent Villeneuve, Olivier Glehen, Armando Sardi, Loma Parikh, Aviram Nissan, Noah Cohen, Anwar Alshukami, Dario Baratti, Paolo Sammartino, Shoma Barat, Kurtis Campbell, Marcello Deraco, Gaurav Goswami, Kaushal Kundalia, Galal Bashanfer, Delia Cortes-Guiral, Faheez Mohamed, Kiran K. Turaga, Mohammad Alyami, David L. Morris, Samer Alammari, Yutaka Yonemura, Vincent C J van de Vlasakker, Mohammad Adileh, Praveen Kammar, Michelle Sittig, Daniele Biacchi, Kathleen Cummins-Perry, P. Rousset |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
oncogenes hepatobiliary tumours Surgical pathology 03 medical and health sciences 0302 clinical medicine medicine Humans Multicenter Studies as Topic Prospective Studies Lymph node Pathological Peritoneal Neoplasms Retrospective Studies Ovarian Neoplasms business.industry gynaecological oncology General Medicine Cytoreduction Surgical Procedures medicine.disease Combined Modality Therapy gastrointestinal imaging Survival Rate Observational Studies as Topic medicine.anatomical_structure Oncology gastrointestinal tumours 030220 oncology & carcinogenesis Radiological weapon Conventional PCI Peritoneal mesothelioma Peritoneal Cancer Index Medicine 030211 gastroenterology & hepatology Female Radiology Neoplasm Recurrence Local Ovarian cancer business Gastrointestinal imaging surgical pathology Colorectal Neoplasms |
| Zdroj: | BMJ Open BMJ Open, Vol 11, Iss 7 (2021) |
| ISSN: | 2044-6055 |
| Popis: | IntroductionDespite optimal patient selection and surgical effort, recurrence is seen in over 70% of patients undergoing cytoreductive surgery (CRS) for peritoneal metastases (PM). Apart from the Peritoneal Cancer Index (PCI), completeness of cytoreduction and tumour grade, there are other factors like disease distribution in the peritoneal cavity, pathological response to systemic chemotherapy (SC), lymph node metastases and morphology of PM which may have prognostic value. One reason for the underutilisation of these factors is that they are known only after surgery. Identifying clinical predictors, specifically radiological predictors, could lead to better utilisation of these factors in clinical decision making and the extent of peritoneal resection performed for different tumours. This study aims to study these factors, their impact on survival and identify clinical and radiological predictors.Methods and analysisThere is no therapeutic intervention in the study. All patients with biopsy-proven PM from colorectal, appendiceal, gastric and ovarian cancer and peritoneal mesothelioma undergoing CRS will be included. The demographic, clinical, radiological, surgical and pathological details will be collected according to a prespecified format that includes details regarding distribution of disease, morphology of PM, regional node involvement and pathological response to SC. In addition to the absolute value of PCI, the structures bearing the largest tumour nodules and a description of the morphology in each region will be recorded. A correlation between the surgical, radiological and pathological findings will be performed and the impact of these potential prognostic factors on progression-free and overall survival determined. The practices pertaining to radiological and pathological reporting at different centres will be studied.Ethics and disseminationThe study protocol has been approved by the Zydus Hospital ethics committee (27 July, 2020) and Lyon-Sud ethics committee (A15-128).Trial registration numberCTRI/2020/09/027709; Pre-results. |
| Databáze: | OpenAIRE |
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