Elimination of oxacillin, its toxicity and antibacterial activity by using ionizing radiation
| Autor: | Tünde Tóth, Erzsébet Takács, László Wojnárovits, Anikó Bezsenyi, Libing Chu, Krisztina J. Kovács, László Szabó, Renáta Homlok, Jianlong Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Environmental Engineering
Health Toxicology and Mutagenesis Population beta-Lactams Water Purification Cloxacillin Radiation Ionizing polycyclic compounds medicine Environmental Chemistry education Oxacillin education.field_of_study Chemistry Chemical oxygen demand Public Health Environmental and Occupational Health General Medicine General Chemistry biochemical phenomena metabolism and nutrition Biodegradation Antimicrobial Pollution Anti-Bacterial Agents Activated sludge Radiolysis Antibacterial activity Nuclear chemistry medicine.drug |
| Zdroj: | Chemosphere. 286(Pt 1) |
| ISSN: | 1879-1298 |
| Popis: | The chemical changes caused by electron beam and γ irradiations and the biochemical characteristics of degradation products of a frequently used antibiotic oxacillin were investigated and compared with those of cloxacillin by applying pulse radiolysis, chemical and biochemical oxygen demand, total organic carbon content, oxygen uptake rate, toxicity and antibacterial activity measurements. Oxacillin was found to be non-toxic, but poorly biodegradable by the mixed microbial population of the activated sludge of a wastewater treatment plant. Therefore, it can significantly contribute to the spread of β-lactam antibiotic resistant bacteria. However, the products formed by γ-irradiation were more easily biodegradable as they were utilized as nutrient source by the microbes of the activated sludge and the products did not show antibacterial activity. During irradiation treatment of aerated aqueous solutions mainly hydroxyl radicals induce the elimination of antimicrobial activity by making alterations at the bicyclic β-lactam part of these antibiotics. Since the β-lactam part is the same in oxacillin and cloxacillin, the biochemical characteristics of products of the two antibiotics are similar. The attack of hydrated electron takes place on the carbonyl groups. When the irradiation is made under anoxic conditions these reactions may also contribute considerably to alterations at the β-lactam part and thereby to the loss of antibacterial activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect