Prestroke selective serotonin reuptake inhibitor use and functional outcomes after ischaemic stroke

Autor: Lee H. Schwamm, Khawja A Siddiqui, Mark R Etherton
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
Weakness
Time Factors
Multivariate analysis
acute stroke
medicine.medical_treatment
Serotonin reuptake inhibitor
030204 cardiovascular system & hematology
behavioral disciplines and activities
Risk Assessment
antidepressive agents
Disability Evaluation
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Ischaemic stroke
Humans
Medicine
Prospective Studies
Registries
Stroke
stroke rehabilitation
Aged
Ischemic Stroke
Retrospective Studies
Aged
80 and over
Univariate analysis
business.industry
Stroke scale
digestive
oral
and skin physiology
Recovery of Function
Middle Aged
medicine.disease
Patient Discharge
Functional Status
Treatment Outcome
Original Article
Female
Neurology (clinical)
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Stroke recovery
Selective Serotonin Reuptake Inhibitors
030217 neurology & neurosurgery
Zdroj: Stroke and Vascular Neurology
ISSN: 2059-8696
2059-8688
DOI: 10.1136/svn-2017-000119
Popis: BackgroundSelective serotonin reuptake inhibitors (SSRIs) have been implicated in contributing to recovery after acute ischaemic stroke. In particular, poststroke initiation of an SSRI has been demonstrated to improve motor recovery. The role of prestroke SSRI use on functional outcomes and stroke recovery is less clear. We aimed to examine the effect of prestroke SSRI use on metrics of hospitalisation and functional recovery.MethodsWe included 4968 consecutive patients from January 2006 to June 2015 in our local Get With The Guidelines-Stroke registry in whom a preadmission drug list could be extracted from an administrative research data registry. Univariate and multivariate analyses were performed to identify predictors of functional outcomes.ResultsOn univariate analysis, among 4698 ischaemic strokes (740 SSRI users and 3948 non-users), SSRI use before acute ischaemic stroke did not impact the National Institutes of Health Stroke Scale (NIHSS) admission score, length of stay or rate of symptomatic haemorrhage. Patients using SSRIs prior to their stroke were more likely to present with weakness (57% vs 47.3%; PConclusionsSSRI use preceding an acute ischaemic stroke is associated with lower rates of discharge to home despite no significant increase in length of stay or NIHSS score.
Databáze: OpenAIRE
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