Metabolic basis for high paracetamol dosage without hepatic injury: a case study
| Autor: | J. M. Tredger, P. Thuluvath, Roger Williams, I. M. Murray-Lyon |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Health
Toxicology and Mutagenesis Metabolite Administration Oral Urine Pharmacology Toxicology 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics medicine Humans Ingestion Cysteine Acetaminophen digestive oral and skin physiology General Medicine Glutathione Middle Aged Liver chemistry 030220 oncology & carcinogenesis Toxicity Female Aminophylline Follow-Up Studies medicine.drug |
| Zdroj: | Human & Experimental Toxicology. 14:8-12 |
| ISSN: | 1477-0903 0960-3271 |
| Popis: | 1 Studies of paracetamol metabolism were performed in a 58-year-old female with rheumatoid arthritis who had consumed 15-20 g paracetamol daily for 5 years with out developing liver damage and data were compared with results in seven normal volunteers. 2 After a test dose of 2 g paracetamol, the formation of paracetamol sulphate and glucuronide conjugates detected in plasma from the patient was delayed by around 2 h relative to values in normal volunteers and the proportion of sulphate conjugates excreted in urine was 1.5 to 2 times those in normal volunteers (52% vs 26-35% of dose, respectively). The fractional metabolite clearance of paracetamol to glutathione-derived conju gates (0.28 ml min-1 kg-1) in our patient was > 30% lower than in normal females. 3 A combination of slow paracetamol absorption, enhanced detoxication of paracetamol (by sulphation) and reduced metabolism to potentially cytotoxic metabolites may have reduced the risk of liver damage in this patient. The latter may have reflected pharmaco- genetic deficiencies in cytochrome P450 isoenzymes per sisting despite chronic alcohol consumption (40—60 g per day) or resulted from inhibition of paracetamol acti vation by concomitant ingestion of aminophylline. |
| Databáze: | OpenAIRE |
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