Longitudinal changes in prospective memory and their clinical correlates at 1-year follow-up in first-episode schizophrenia

Autor: Yan Zhou, Yu-Tao Xiang, Liang Zhang, Chee H. Ng, Fu-Chun Zhou, David W. K. Man, Gabor S. Ungvari, Jingjing Zhou, Chuanyue Wang, Jun Li, David Shum, Deng Tang Liu
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Social Sciences
lcsh:Medicine
Neuropsychological Tests
Severity of Illness Index
0302 clinical medicine
Cognition
Learning and Memory
Sociology
Prospective memory
Medicine and Health Sciences
Medicine
Antipsychotics
Psychology
Longitudinal Studies
Prospective Studies
Prospective cohort study
lcsh:Science
Cognitive Impairment
Multidisciplinary
Cognitive Neurology
Remission Induction
Drugs
Middle Aged
Phenotype
Neurology
Schizophrenia
Research Design
Female
Analysis of variance
Research Article
Adult
medicine.medical_specialty
China
Adolescent
Patients
Memory
Episodic
Cognitive Neuroscience
Research and Analysis Methods
Education
03 medical and health sciences
Young Adult
Memory
Internal medicine
Severity of illness
Mental Health and Psychiatry
Humans
Learning
Educational Attainment
Pharmacology
Analysis of Variance
Memory Disorders
business.industry
lcsh:R
Cognitive Psychology
Repeated measures design
Biology and Life Sciences
medicine.disease
030227 psychiatry
Health Care
Social Class
Endophenotype
Case-Control Studies
Cognitive Science
lcsh:Q
business
Neurocognitive
030217 neurology & neurosurgery
Follow-Up Studies
Neuroscience
Zdroj: PLoS ONE, Vol 12, Iss 2, p e0172114 (2017)
PLoS ONE
ISSN: 1932-6203
Popis: This study aimed to investigate prospective memory (PM) and the association with clinical factors at 1-year follow-up in first-episode schizophrenia (FES). Thirty-two FES patients recruited from a university-affiliated psychiatric hospital in Beijing and 17 healthy community controls (HCs) were included. Time- and event-based PM (TBPM and EBPM) performances were measured with the Chinese version of the Cambridge Prospective Memory Test (C-CAMPROMPT) at baseline and at one-year follow-up. A number of other neurocognitive tests were also administered. Remission was determined at the endpoint according to the PANSS score ≤ 3 for selected items. Repeated measures analysis of variance revealed a significant interaction between time (baseline vs. endpoint) and group (FES vs. HCs) for EBPM (F(1, 44) = 8.8, p = 0.005) and for all neurocognitive components. Paired samples t-tests showed significant improvement in EBPM in FES (13.1±3.7 vs. 10.3±4.8; t = 3.065, p = 0.004), compared to HCs (15.7±3.6 vs. 16.5±2.3; t = -1.248, p = 0.230). A remission rate of 59.4% was found in the FES group. Analysis of covariance revealed that remitters performed significantly better on EBPM (14.9±2.6 vs. 10.4±3.6; F(1, 25) = 12.2, p = 0.002) than non-remitters at study endpoint. The association between EBPM and 12-month clinical improvement in FES suggests that EBPM may be a potential neurocognitive marker for the effectiveness of standard pharmacotherapy. Furthermore, the findings also imply that PM may not be strictly a trait-related endophenotype as indicated in previous studies.
Databáze: OpenAIRE
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