CHIP: A new modulator of human malignant disorders
| Autor: | Guanqiao Li, Taiping Zhang, Qian-Qian Shao, Gang Yang, Zhe Cao, Lianfang Zheng, Yupei Zhao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
biology CHIP Ubiquitin-Protein Ligases Review Computational biology Protein Homeostasis ubiquitination Chip 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology Ubiquitin Neoplasms 030220 oncology & carcinogenesis biology.protein Humans cancer co-chaperon |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.8219 |
| Popis: | Carboxyl terminus of Hsc70-interacting protein (CHIP) is known as a chaperone-associated E3 for a variety of protein substrates. It acts as a link between molecular chaperones and ubiquitin–proteasome system. Involved in the process of protein clearance, CHIP plays a critical role in maintaining protein homeostasis in diverse conditions. Here, we provide a comprehensive review of our current understanding of CHIP and summarize recent advances in CHIP biology, with a focus on CHIP in the setting of malignancies. |
| Databáze: | OpenAIRE |
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