Néphropathie cristalline secondaire au méthotrexate : une entité rarement objectivée sur biopsie rénale
| Autor: | Sophie Félix, Prudence Colpart |
|---|---|
| Přispěvatelé: | Service d'Anatomie pathologique [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Kidney Pathology medicine.medical_specialty Acute Renal Injury medicine.diagnostic_test business.industry [SDV]Life Sciences [q-bio] medicine.disease 3. Good health Pathology and Forensic Medicine Lymphoma 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Biopsy medicine Methotrexate Renal biopsy business medicine.drug |
| Zdroj: | Annales de Pathologie Annales de Pathologie, Elsevier Masson, 2019, 39, pp.18-23. ⟨10.1016/j.annpat.2018.08.005⟩ |
| ISSN: | 0242-6498 |
| DOI: | 10.1016/j.annpat.2018.08.005⟩ |
| Popis: | Drug-induced crystalline nephropathies are secondary to abnormal accumulation of crystals leading to parenchymal renal injuries. Methotrexate, used to treat a wide range of malignancies, is one of the various drugs accountable in this particular condition. We report a case of acute renal injury during the course of high-dose methotrexate therapy in a patient presenting primary cerebral diffuse large B-cell lymphoma. Interestingly, the kidney biopsy revealed intratubular methotrexate crystal formations. We also summarize the distinctive characteristics of main crystalline nephropathies in order to guide pathologists toward the many types of crystals encountered on renal biopsy. |
| Databáze: | OpenAIRE |
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