Hyperkeratotic hand eczema
Autor: | Sabrina Z. Jan, Peter C. van den Akker, Henny H. Lemmink, Gilles F. H. Diercks, Marie L A Schuttelaar, Maria C. Bolling, Hendri H. Pas, Laura Loman, Klaziena Politiek |
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Přispěvatelé: | Microbes in Health and Disease (MHD), Translational Immunology Groningen (TRIGR), Public Health Research (PHR) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male Pathology medicine.medical_specialty Dermatology hyperkeratotic hand eczema Filaggrin Proteins Dermatitis Atopic palmar psoriasis Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Keratin Humans Immunology and Allergy Medicine 030212 general & internal medicine skin and connective tissue diseases Involucrin pathophysiology chemistry.chemical_classification Hyperkeratosis Epidermolytic integumentary system business.industry keratinocyte differentiation immunofluorescence microscopy Original Articles medicine.disease Immunohistochemistry Up-Regulation Palmoplantar keratoderma chemistry Hand eczema Loricrin Keratins Female Histopathology Original Article eczema business Biomarkers Filaggrin |
Zdroj: | Contact Dermatitis CONTACT DERMATITIS, 83(3), 196-205. Wiley |
ISSN: | 1600-0536 0105-1873 |
Popis: | BACKGROUND: Hyperkeratotic hand eczema (HHE) is a typical clinical hand eczema subtype with a largely unknown pathophysiology.OBJECTIVE: To investigate histopathology, expression of keratins (K), epidermal barrier proteins, and adhesion molecules in HHE.METHODS: Palmar skin biopsies (lesional and perilesional) were obtained from seven HHE patients and two healthy controls. Moreover, 135 candidate genes associated with palmoplantar keratoderma were screened for mutations.RESULTS: Immunofluorescence staining showed a significant reduction of K9 and K14 in lesional skin. Upregulation was found for K5, K6, K16, and K17 in lesional skin compared with perilesional and healthy palmar skin. Further, upregulation of involucrin and alternating loricrin staining, both in an extracellular staining pattern, was found. Filaggrin expression was similar in lesional, perilesional, and control skin. No monogenetic mutations were found.CONCLUSION: Currently, the phenotype of HHE is included in the hand eczema classification system; however, it can be argued whether this is justified. The evident expression of filaggrin and involucrin in lesional skin does not support a pathogenesis of atopic eczema. The upregulation of K6, K16, and K17 and reduction of K9 and K14 might contribute to the underlying pathogenesis. Unfortunately, comparison with hand eczema studies is not possible yet, because similar protein expression studies are lacking. |
Databáze: | OpenAIRE |
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