Dynamic and conformational switching in proteins
| Autor: | S. Rackovsky, Harold A. Scheraga |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Quantitative Biology::Biomolecules
Work (thermodynamics) Dynamic switching Protein Conformation 010405 organic chemistry Chemistry Protein dynamics Organic Chemistry Biophysics Computational Biology Proteins General Medicine 010402 general chemistry 01 natural sciences Biochemistry Protein Structure Secondary Article 0104 chemical sciences Biomaterials Biological system Sequence (medicine) |
| Zdroj: | Biopolymers |
| ISSN: | 1097-0282 0006-3525 |
| DOI: | 10.1002/bip.23411 |
| Popis: | Using bioinformatic methods for treating protein dynamics, developed in earlier work, we study the relationship between sequence mobility and dynamics in proteins. It is shown that sequence mobility drives a transition between two dynamic regimes in proteins, and that the specific details of this transition differ qualitatively between α-helical proteins and those in other structural classes. We examine the possibility that conformational switching is related to dynamic switching, by considering a specific system of sequences which exhibit the switching phenomenon. It is shown that a relationship between dynamic and conformational switching is entirely plausible. |
| Databáze: | OpenAIRE |
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