Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
| Autor: | Kenji Nakanishi, Nobuki Hayashi, Kathy Hsiao, Hiroko Tsutsui, Kazuya Higashino, Michael S.-S. Su, Richard A. Flavell, Masashi Kurimoto, Mark A. Fleming, George Ku, Yong Gu, Matthew W. Harding, Keisuke Kuida, Tadao Tanimoto, David J. Livingston, Vicki L. Sato, Haruki Okamura |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide Kupffer Cells Caspase 1 Inflammation Transfection Proinflammatory cytokine chemistry.chemical_compound Interferon-gamma Mice medicine Animals Humans Interferon gamma Protein Precursors Caspase Multidisciplinary biology Caspase 3 Kupffer cell Interleukin-18 Molecular biology Caspases Initiator Recombinant Proteins Cysteine Endopeptidases medicine.anatomical_structure chemistry Biochemistry Caspases Culture Media Conditioned COS Cells biology.protein Cytokines Interleukin 18 medicine.symptom Protein Processing Post-Translational Spleen medicine.drug |
| Zdroj: | Science (New York, N.Y.). 275(5297) |
| ISSN: | 0036-8075 |
| Popis: | The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-γ inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE−/−) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-γ and IGIF were diminished in the sera of ICE−/−mice exposed toPropionibacterium acnesand lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE−/−mice may account for their protection from septic shock. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|