The possible role of a central nervous system dopaminergic mechanism in hepatic c-fos protein expression following peritoneal sepsis
| Autor: | Kelly J. Cain, Richard Charboneau, Roderick A. Barke, Rebecca B. Chapin, Sabita Roy |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Dopamine Central nervous system Receptors Dopamine Sepsis Rats Sprague-Dawley chemistry.chemical_compound Genes jun Internal medicine medicine Haloperidol Animals Receptor SCH-23390 business.industry Dopaminergic Antagonist Brain Genes fos medicine.disease Rats medicine.anatomical_structure Endocrinology chemistry Liver Dopamine Antagonists Surgery business medicine.drug |
| Zdroj: | Archives of surgery (Chicago, Ill. : 1960). 130(11) |
| ISSN: | 0004-0010 |
| Popis: | Objective: To investigate the hypothesis that a central dopaminergic mechanism may regulate hepatic c-fosand c-jungene expression following peritoneal sepsis. Methods: First, dopamine or vehicle was instilled into a stereotaxically placed intracerebral-ventricular (ICV) cannula with or without D1(SCH 23390) or D2(haloperidol) antagonist pretreatment in a rat model, and the effect on hepatic c-fosor c-junprotein expression was investigated. Second, we investigated the effect of haloperidol and vehicle treatment following cecal ligation and puncture (CLP)–induced sepsis with respect to hepatic c-fosprotein expression, c-junprotein expression, and survival. Results: Intracerebral-ventricular dopamine treatment increased hepatic c-fos immunoreactive protein but had no effect on hepatic c-jun immunoreactive protein expression. Pretreatment with SCH 23390 inhibited ICV dopamine treatment–induced hepatic c-fosimmunore-active protein expression. Haloperidol pretreatment synergized with ICV dopamine treatment to overexpress hepatic c-fosprotein. Haloperidol treatment significantly increased CLP-induced hepatic c-fosand c-junprotein expression and improved survival following CLP. Conclusions: Hepatic c-fosprotein expression may be regulated, in part, by a central nervous system—mediated dopaminergic D1receptor mechanism. Treatment with the D2receptor antagonist, haloperidol, increases sepsis-induced hepatic c-fosand c-junprotein expression and improves survival following peritoneal contamination. (Arch Surg. 1995;130:1209-1216) |
| Databáze: | OpenAIRE |
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