Eotaxin Is a Potent Chemotaxin for Human Basophils
| Autor: | Yutaka Morita, Misato Miyamasu, Koji Ito, Koichi Hirai, Toshiaki Takaishi, Yoshikata Misaki, Tadashi Kasahara, Motoyasu Iikura, Hirokazu Yamada, Shunsuke Shoji |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Chemokine CCL11
Eotaxin Chemotactic Factors Eosinophil Cell Biophysics chemical and pharmacologic phenomena Biochemistry Allergic inflammation chemistry.chemical_compound medicine Humans RNA Messenger Receptor CCL13 Molecular Biology Leukotriene hemic and immune systems Chemotaxis Cell Biology respiratory system Basophils medicine.anatomical_structure chemistry Chemokines CC Immunology Cytokines Chemokines Histamine |
| Zdroj: | Biochemical and Biophysical Research Communications. 231:365-368 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1997.6100 |
| Popis: | We studied the effect of eotaxin, a novel eosinophil-active CC chemokine with high target cell specificity, on human basophils. Eotaxin induced higher levels of chemotactic response with a lower ED50 compared with RANTES in basophils; half-maximal migration occurred at a concentration of approximately 3 nM. On the other hand, it exerted only a marginal effect on either histamine release or leukotriene C4 generation. In addition, nested PCR amplification experiments revealed the expression of CC CKR3, a putative receptor for eotaxin, on basophils. Since accumulation of both basophils and eosinophils is an important aspect of allergic inflammation, eotaxin potentially plays a pathogenic role in allergic disorders by inducing migration of both of these cell types. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect