Quality of life, functional outcomes, and wound complications in patients with soft tissue sarcomas treated with preoperative chemoradiation: a prospective study
| Autor: | Norman S. Schachar, Shannon S. Puloski, Kathryn Lanuke, Lloyd A. Mack, Michael Kwan, Allison Fyfe, Elizabeth Kurien, Justin D. Rivard, Walley J. Temple |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Preoperative care Young Adult Quality of life Surgical oncology Antineoplastic Combined Chemotherapy Protocols Preoperative Care medicine Humans Prospective Studies Young adult Prospective cohort study Neoadjuvant therapy Aged Neoplasm Staging Aged 80 and over business.industry Soft tissue Sarcoma Chemoradiotherapy Middle Aged Limb Salvage Prognosis Neoadjuvant Therapy Surgery Oncology Quality of Life Wounds and Injuries Female Neoplasm Grading business Follow-Up Studies |
| Zdroj: | Annals of surgical oncology. 22(9) |
| ISSN: | 1534-4681 |
| Popis: | Preoperative irradiation reduces local recurrence of soft tissue sarcomas (STSs), but major wound complication rates approach 25–35 %. Using a novel neoadjuvant chemoradiation protocol, we prospectively documented functional outcomes and quality of life (QOL) and hypothesized a lower major wound complication rate. Patients with STS deep to muscular fascia were treated with 3 days of doxorubicin (30 mg/day) and 10 days of irradiation (300 cGy/day) followed by limb-sparing surgery. Wound complications were assessed, and functional assessment and QOL were followed prospectively using the Toronto Extremity Salvage Score (TESS), Musculoskeletal Tumor Society (MSTS), and Short Form (SF)-36 questionnaires preoperatively and 6 and 12 months postoperatively. Altogether, 52 consecutive patients were accrued during 2006–2011. Overall, 80.8 % of STSs were >5 cm, and 67.3 % involved the lower extremity. Seven (13.5 %) major wound complications occurred, all requiring reoperation. Preoperative scores for TESS, MSTS, and SF-36 physical (PCS) and mental (MCS) health components were 83.3, 86.7, 40.6, and 49.4, respectively. There were no differences seen 6 months postoperatively. By 12 months, however, patients showed improved functional scores (TESS 93.0, p = 0.02; MSTS 93.3, p |
| Databáze: | OpenAIRE |
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