T-cell co-stimulation through B7RP-1 and ICOS
| Autor: | Gary Elliott, Grace Shih, Ming Zhang, Gwyneth Van, Pauline Campbell, Christine L. Shaklee, Tak W. Mak, John Whoriskey, Ulla Sarmiento, Jane Guo, Tadahiko Kohno, David Chang, Ariela Hui, Marco A. Coccia, Tom Horan, Tianang Dai, Anna Tafuri-Bladt, Laura Chiu, Giorgio Senaldi, Sheila Scully, David W. Brankow, Susan McCabe, Gordon S. Duncan, Steven Kiyoshi Yoshinaga, Sanjay D. Khare, Arda Shahinian |
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| Rok vydání: | 1999 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte DNA Complementary Recombinant Fusion Proteins T-Lymphocytes T cell Molecular Sequence Data Gene Expression Mice Transgenic CHO Cells Biology Dermatitis Contact Ligands Lymphocyte Activation Inducible T-Cell Co-Stimulator Protein Inducible T-Cell Co-Stimulator Ligand Mice Immune system Co-stimulation Cricetinae medicine Animals Humans Amino Acid Sequence Cells Cultured Mice Inbred BALB C Multidisciplinary COS cells Sequence Homology Amino Acid T-cell receptor CD28 Acquired immune system Cell biology Mice Inbred C57BL ICOS LIGAND medicine.anatomical_structure COS Cells Immunology B7-1 Antigen Female Lymph Nodes Protein Binding |
| Zdroj: | Nature. 402:827-832 |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | T-cell activation requires co-stimulation through receptors such as CD28 and antigen-specific signalling through the T-cell antigen receptor. Here we describe a new murine costimulatory receptor-ligand pair. The receptor, which is related to CD28 and is the homologue of the human protein ICOS, is expressed on activated T cells and resting memory T cells. The ligand, which has homology to B7 molecules and is called B7-related protein-1 (B7RP-1), is expressed on B cells and macrophages. ICOS and B7RP-I do not interact with proteins in the CD28-B7 pathway, and B7RP-1 co-stimulates T cells in vitro independently of CD28. Transgenic mice expressing a B7RP-1-Fc fusion protein show lymphoid hyperplasia in the spleen, lymph nodes and Peyer's patches. Presensitized mice treated with B7RP-1-Fc during antigen challenge show enhanced hypersensitivity. Therefore, B7RP-1 exhibits co-stimulatory activities in vitro and in vivo. ICOS and B7RP-1 define a new and distinct receptor-ligand pair that is structurally related to CD28-B7 and is involved in the adaptive immune response. |
| Databáze: | OpenAIRE |
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