Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma: A hospital-based case-control study
| Autor: | Magoni, M, Apostoli, P, Donato, F, Manganoni, A, Comba, P, Fazzo, L, Speziani, F, Leonardi, L, Orizio, G, Scarcella, C, Calzavara Pinton, P, Terraroli, C, Coniglio, A, Zarattini, G, Manca, G, Fostinelli, J, Festa, R, Conti, M, Micheletti, S |
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| Rok vydání: | 2018 |
| Předmět: |
Risk
Skin Neoplasms Population Physiology 010501 environmental sciences 01 natural sciences Environmental risk factors Melanoma Polychlorinated biphenyls 2300 03 medical and health sciences 0302 clinical medicine medicine Humans education lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 education.field_of_study business.industry Case-control study Cancer Hospital based Plasma levels medicine.disease Control subjects Quartile Case-Control Studies 030220 oncology & carcinogenesis business |
| Zdroj: | Environment International, Vol 113, Iss, Pp 20-25 (2018) |
| ISSN: | 0160-4120 |
| DOI: | 10.1016/j.envint.2018.01.018 |
| Popis: | Polychlorinated biphenyls (PCB) have been classified by the International Agency for Research on Cancer (IARC) in Group 1 as carcinogenic to human, based on sufficient evidence in humans of an increased risk of cutaneous malignant melanoma (CMM), however few studies have been done in the general population. This study examined the relationship between PCB plasma levels and risk of CMM adjusting for sun sensitivity and sun exposure in a province of Northern Italy (Brescia), where a chemical factory produced PCBs from 1938 to 1984 causing human contamination. A case–control study of 205 CMM patients and 205 control subjects was conducted. Cases and controls were assayed for plasma levels of 33 PCB congeners. No associations was found between risk of CMM and plasma levels of total PCB (OR = 0.81; 95% CI: 0.34–1.96 for highest vs lowest quartile) or specific congeners. The study confirmed the association with light skin colour (OR = 3.00; 95% CI: 1.91–4.73), cumulative lifetime UV exposure (OR = 2.56; 95% CI: 1.35–4.85) and high level of education (OR = 1.45; 95% CI: 1.03–2.05). This case-control study does not support the hypothesis of an association between current plasma levels of PCBs and CMM development in the general population. Keywords: Melanoma, Polychlorinated biphenyls, Environmental risk factors |
| Databáze: | OpenAIRE |
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