Effect of Donation Time on Platelet Concentrates and Fresh-Frozen Plasma. An in vitro Study
| Autor: | Geoffrey G. Giacco, Benjamin Lichtiger, Benjamin Drewinko, Yang O. Huh, Vincent F. Guinee |
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| Rok vydání: | 1989 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Time Factors Fibrinopeptide A Blood cell Plasma Internal medicine Blood plasma medicine Humans In vitro study Platelet Platelet concentrate Antigens Blood Specimen Collection Factor VIII biology Platelet Count Chemistry Factor V Hematology General Medicine Hydrogen-Ion Concentration Endocrinology medicine.anatomical_structure Immunology biology.protein Fresh frozen plasma |
| Zdroj: | Vox Sanguinis. 56:21-24 |
| ISSN: | 1423-0410 0042-9007 |
| Popis: | To investigate the effect of donation time on the quality of blood components, we measured the platelet count and pH on platelet concentrates, and the factor V and VIII:C levels and fibrinopeptide A concentration on fresh-frozen plasma by duration of donation time. Platelet concentrates and fresh-frozen plasma were classified into three groups according to donation time: group 1, less than 10 min; group 2, 10-15 min, and group 3, longer than 15 min. Mean platelet counts of platelet concentrate were: group 1, 8.6 +/- 2.5 (in x 10(10], group 2, 8.1 +/- 2.6, and group 3, 6.5 +/- 3.2 (p less than 0.05). The same pH was maintained in all three groups. The fibrinopeptide A concentrations in groups 1 and 2 were 24 +/- 53 and 169 +/- 64 ng/ml, respectively, while in group 3 all were greater than 200 ng/ml, indicating correlation of a higher fibrinopeptide A level with longer donation time. Although a higher fibrinopeptide A level indicated a greater degree of thrombin generation, assays of factors V and VII:C did not show decreased activity in groups 2 and 3. |
| Databáze: | OpenAIRE |
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