Association Between the IL-6 rs1800795 Polymorphism and the Risk of Cervical Cancer: A Meta-Analysis of 1210 Cases and 1525 Controls
| Autor: | Yan Zhang, Ning Tang, Dan Lyu, Lianbing Sheng, Haiping Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Genotype Population Uterine Cervical Neoplasms Bioinformatics Polymorphism Single Nucleotide Linkage Disequilibrium 03 medical and health sciences 0302 clinical medicine Internal medicine Genetic model medicine Odds Ratio Humans Genetic Predisposition to Disease Interleukin 6 education Alleles Genetic Association Studies Cervical cancer education.field_of_study biology business.industry Interleukin-6 Odds ratio Original Articles medicine.disease Confidence interval 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Case-Control Studies biology.protein Female business |
| Popis: | Cervical cancer is the second most common cancer and the third leading cause of cancer-related death among females in less developed countries. Studies have shown that the single-nucleotide polymorphisms of interleukin 6 might be associated with cervical cancer risk. A total of 710 articles from EMBASE, EBSCO, Web of science, PubMed, Springer link, and Chinese National Knowledge Infrastructure databases were reviewed in our study. A meta-analysis on the associations between interleukin 6 rs1800795 polymorphism and cervical cancer risk was carried out by comparison using 5 genetic models. In this systematic review, 5 studies were analyzed. The pooled population included 2735 participants (1210 cases and 1525 controls). The overall odds ratio (G vs C alleles) using fixed-effects model was 0.85 (95% confidence interval 0.75-0.97), P = .02. Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. Our results indicate that interleukin 6 rs1800795 polymorphism might be associated with susceptibility to cervical cancer. |
| Databáze: | OpenAIRE |
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