Potential of radiolabelled PSMA PET/CT or PET/MRI diagnostic procedures in gliomas/glioblastomas
| Autor: | Elisabetta Cerudelli, Maria Gazzilli, Francesco Bertagna, Raffaele Giubbini, Domenico Albano, Giorgio Treglia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
positron emission tomography Mri imaging Population PET PSMA glioblastoma glioma prostate specific membrane antibodies urologic and male genital diseases digestive system Multimodal Imaging 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine Glioma Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging In patient Whole Body Imaging Psma pet ct education Pharmacology Pediatric education.field_of_study medicine.diagnostic_test business.industry Brain Neoplasms Prostate-Specific Antigen medicine.disease Magnetic Resonance Imaging Brain Neoplasms/diagnostic imaging Glioblastoma/diagnostic imaging Glioma/diagnostic imaging Magnetic Resonance Imaging/methods Multimodal Imaging/methods Positron Emission Tomography Computed Tomography/methods Positron-Emission Tomography/methods Radiopharmaceuticals Whole Body Imaging/methods Positron emission tomography 030220 oncology & carcinogenesis Positron-Emission Tomography Nuclear medicine business Glioblastoma |
| Zdroj: | Current radiopharmaceuticals, vol. 13, no. 2, pp. 94-98 Current Radiopharmaceuticals |
| Popis: | Background: Radiolabeled prostate-specific membrane antigen PSMA-based PET/CT or PET/MRI is a whole-body imaging technique currently performed for the detection of prostate cancer lesions. PSMA has been also demonstrated to be expressed by the neovasculature of many other solid tumors. Objective: The aim of this review is to evaluate the possible diagnostic role of radiolabeled PSMA PET/CT or PET/MRI in patients with gliomas and glioblastomas, by summarizing the available literature data. Methods: A comprehensive literature search of the PubMed/MEDLINE, Scopus, Embase and Cochrane library databases was conducted to find relevant published articles about the diagnostic performance of radiolabeled PSMA binding agents in PET/CT or PET/MRI imaging of patients with suspected gliomas or glioblastomas. Results: Seven case reports or case series and 3 studies enrolling more than 10 patients showed that gliomas and glioblastoma are PSMA-avid tumors. Conclusion: Radiolabeled PSMA imaging seems to be useful in analyzing glioma/glioblastoma. Further studies enrolling a wider population are needed to clarify the real clinical and diagnostic role of radiolabeled PSMA in this setting and its possible position in the diagnostic flow-chart. |
| Databáze: | OpenAIRE |
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