Performance and cutoffs for liver fibrosis staging of a two-dimensional shear wave elastography technique
| Autor: | Carolina Dellafiore, Carmine Tinelli, Elisabetta Above, Laura Maiocchi, Carlo Filice, Giovanna Ferraioli |
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| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
Male Cirrhosis Chronic liver disease 03 medical and health sciences 0302 clinical medicine Japan Fibrosis medicine Humans Hepatology Receiver operating characteristic medicine.diagnostic_test business.industry Ultrasound Gastroenterology medicine.disease Cross-Sectional Studies Liver ROC Curve 030220 oncology & carcinogenesis Elasticity Imaging Techniques 030211 gastroenterology & hepatology Female Elastography Steatosis Nuclear medicine business Transient elastography |
| Zdroj: | European journal of gastroenterologyhepatology. 33(1) |
| ISSN: | 1473-5687 |
| Popis: | To assess performance and cutoffs of the 2-dimensional shear wave elastography technique available on the Aplio i800 ultrasound system (Canon Medical Systems, Japan), using transient elastography as reference standard, and to assess the correlation of shear-wave-speed dispersion with liver fibrosis or steatosis.This was a single-center cross-sectional study. The correlations between values obtained with transient elastography and 2-dimensional-shear wave elastography, and between shear-wave-speed dispersion and fibrosis or steatosis, were assessed with Pearson's r. The diagnostic performance of the 2-dimensional-shear wave elastography for staging significant fibrosis and severe fibrosis compared to transient elastography was assessed using the area under the receiver operating characteristic curve analysis.Three hundred sixty-seven patients (198 males and 169 females) were studied. There was a high correlation between 2-dimensional-shear wave elastography and transient elastography (r = 0.87, P0.0001). The area under the receiver operating characteristics of 2-dimensional-shear wave elastography for staging significant fibrosis (F2) and severe fibrosis (F3-F4), respectively, were 0.97 (95% confidence interval, 0.91-0.98) and 0.97 (95% confidence interval, 0.95-0.99). The best cutoffs for significant fibrosis and severe fibrosis, respectively, were7 and9 kPa. Shear-wave-speed dispersion showed a high correlation with fibrosis (r = 0.85, P0.0001), whereas there was a very weak correlation with steatosis.The results of this study show that this 2-dimensional-shear wave elastography technique is accurate for staging liver fibrosis. Shear-wave-speed dispersion is highly correlated with liver fibrosis but not with steatosis. |
| Databáze: | OpenAIRE |
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