A Bridge to Coordination Isomer Selection in Lanthanide(III) DOTA-tetraamide Complexes
| Autor: | Zoltan Kovacs, Garry E. Kiefer, Gyula Tircsó, Simon G. Bott, Doug Ogrin, Jimin Ren, Mark Woods, A. Dean Sherry, Piyu Zhao, Jeff Vipond |
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| Rok vydání: | 2007 |
| Předmět: |
Models
Molecular Steric effects Lanthanide Magnetic Resonance Spectroscopy Coordination sphere Stereochemistry Crystallography X-Ray Lanthanoid Series Elements Article Inorganic Chemistry Heterocyclic Compounds 1-Ring chemistry.chemical_compound Isomerism Cyclen DOTA Physical and Theoretical Chemistry Coordination geometry Molecular Structure Ligand Water Amides Oxygen Solutions Coordination isomerism Crystallography Cross-Linking Reagents chemistry |
| Zdroj: | Inorganic Chemistry. 46:2584-2595 |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/ic062184+ |
| Popis: | Interest in macrocyclic lanthanide complexes such as DOTA is driven largely through interest in their use as contrast agents for MRI. The lanthanide tetraamide derivatives of DOTA have shown considerable promise as PARACEST agents, taking advantage of the slow water exchange kinetics of this class of complex. We postulated that water exchange in these tetraamide complexes could be slowed even further by introducing a group to sterically encumber the space above the water coordination site, thereby hindering the departure and approach of water molecules to the complex. The ligand 8O2-bridged DOTAM was synthesized in a 34% yield from cyclen. It was found that the lanthanide complexes of this ligand did not possess a water molecule in the inner coordination sphere of the bound lanthanide. The crystal structure of the ytterbium complex revealed that distortions to the coordination sphere were induced by the steric constraints imposed on the complex by the bridging unit. The extent of the distortion was found to increase with increasing ionic radius of the lanthanide ion, eventually resulting in a complete loss of symmetry in the complex. Because this ligand system is bicyclic, the conformation of each ring in the system is constrained by that of the other; in consequence, inclusion of the bridging unit in the complexes means only a twisted square, antiprismatic coordination geometry is observed for lanthanide complexes of 8O2-bridged DOTAM. |
| Databáze: | OpenAIRE |
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