Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta
| Autor: | Alexander Steinkasserer, Christine Kuhnt, Golo Henning, Edgar Meinl, Monika Kruse, Thomas Berger, Susanne Berchtold, Gerold Schuler |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Cellular differentiation
Immunology Epitopes T-Lymphocyte Immunoglobulins Receptors Cell Surface Biology Lymphocyte Activation Measles virus Signaling lymphocytic activation molecule Downregulation and upregulation Adjuvants Immunologic Signaling Lymphocytic Activation Molecule Family Member 1 Antigens CD Immunology and Allergy Humans Protein Isoforms RNA Messenger CD40 Antigens Receptor Cells Cultured Glycoproteins Membrane Glycoproteins Cell Membrane Antibodies Monoclonal Cell Differentiation Dendritic Cells biology.organism_classification Intercellular Adhesion Molecule-1 Cell biology Up-Regulation Membrane glycoproteins biology.protein Signal transduction Antibody Lymphocyte Culture Test Mixed Peptides Interleukin-1 Signal Transduction T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 167(4) |
| ISSN: | 0022-1767 |
| Popis: | Signaling lymphocyte activation molecule (SLAM), a 70-kDa costimulatory molecule that mediates CD28-independent proliferation of T cells and IFN-γ production, has been identified on human T cells, immature thymocytes, and a subset of B cells. We have found that SLAM is expressed on mature but not immature dendritic cells (DC). However, the SLAM-associated protein, is missing in DC. SLAM surface expression is strongly up-regulated by IL-1β. Addition of IL-1β to the DC maturation mixture also increases the stimulatory properties of DC. These findings provide a new marker for DC maturation and help to explain two areas of DC biology. First, SLAM is a receptor for the measles virus, previously shown to infect DC. Second, SLAM could possibly contribute to the enhanced immunostimulatory functions of DC that are observed following the addition of IL-1. |
| Databáze: | OpenAIRE |
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