The 'Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies' (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants
| Autor: | Ingrid Rýznarová, Mauro Di Bari, Anna Skalska, Marco Pahor, Annemie M. W. J. Schols, Timo E. Strandberg, Riccardo Calvani, Regina Roller-Wirnsberger, Ellen Freiberger, Marcello Maggio, Roberto Bernabei, Francesco Landi, Matteo Cesari, Alan J. Sinclair, Matteo Tosato, Fabrizia Lattanzio, Bruno Vellas, Alfonso J. Cruz-Jentoft, Susanna Del Signore, Thierry Dantoine, Jos M. G. A. Schols, Jérôme Msihid, Cornel C. Sieber, Ronenn Roubenoff, Palmi V. Jonsson, Leocadio Rodríguez-Mañas, Antonio Cherubini, Eva Topinkova, Tomasz Grodzicki, Emanuele Marzetti, Alfons Ramel, Raphaël Bejuit |
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| Přispěvatelé: | Timo Strandberg / Principal Investigator, Department of Medicine, Geriatrian yksikkö, Clinicum, University of Helsinki, HUS Internal Medicine and Rehabilitation, Faculty of Medicine (UI), Læknadeild (HÍ), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands (HÍ), University of Iceland (UI) |
| Rok vydání: | 2018 |
| Předmět: |
Male
Gerontology Sarcopenia Aging Functional impairment Mobility disability Physical performance Prevention Recruitment Skeletal muscle Cost-Benefit Analysis Biochemistry law.invention Disability Evaluation 0302 clinical medicine Endocrinology Randomized controlled trial law STRENGTH 80 and over Medicine 030212 general & internal medicine Aged 80 and over Cost–benefit analysis 3. Good health Italy OBESITY SKELETAL-MUSCLE Treatment strategy Female Hreyfihömlun HEALTH ABC WALK TEST Beinin Frail Elderly AGE-RELATED-CHANGES Accidental Falls Aged Humans Quality of Life Exercise Mobility Limitation Patient Selection 03 medical and health sciences Genetics Hreyfifærni Molecular Biology business.industry Settore MED/09 - MEDICINA INTERNA ADULTS Cell Biology PERFORMANCE medicine.disease Comorbidity LOWER-EXTREMITY FUNCTION 3121 General medicine internal medicine and other clinical medicine Case finding Catchment area business Older people 030217 neurology & neurosurgery |
| Zdroj: | Experimental Gerontology. 113:48-57 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2018.09.017 |
| Popis: | Publisher's version (útgefin grein) Background:The ongoing “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment stra-tegies (SPRINTT)” randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention inthe prevention of mobility disability in older adults with physical frailty & sarcopenia (PF&S). Here, we describethe procedures followed for PF&S case finding and screening of candidate participants for the SPRINTT RCT. Wealso illustrate the main demographic and clinical characteristics of eligible screenees.Methods:The identification of PF&S was based on the co-occurrence of three defining elements: (1) reducedphysical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) lowmuscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3)absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT wasadvertised through a variety of means. Site-specific case finding strategies were developed to accommodate thevariability across centers in catchment area characteristics and access to the target population. A quick “parti-cipant profiling” questionnaire was devised to facilitate PF&S case finding.Results:During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sitesresulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participatingin the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidityburden. In most centers, project advertisement through mass media was the most rewarding case findingstrategy.Conclusion:PF&S case finding in the community is a challenging, but feasible task. Although largely autonomousin daily life activities, older adults with PF&S suffer from significant functional impairment and comorbidity.This subset of the older population is therefore at high risk for disability and other negative health-relatedevents. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass com-munication methods. The present work was funded by a grant from the InnovativeMedicines Initiative - Joint Undertaking (IMI-JU 115621). The workwas also partly supported by the nonprofit research foundation “CentroStudi Achille e Linda Lorenzon” and by intramural research grants fromthe Università Cattolica del Sacro Cuore (D3.2 2013 and D3.2 2015).The authors thank all the participants and the staff involved in thetrial for the enthusiastic participation and dedication. |
| Databáze: | OpenAIRE |
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