How to Make Drugs Orally Active: A Substrate Template for Peptide Transporter PepT1

Autor:	J. Ramsey Bronk, C S Temple, Keith M. Morgan, Ian D. Collier, Patrick D. Bailey, David Meredith, C. A. Richard Boyd
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Molecular model Stereochemistry Substrate (chemistry) Peptide Transporter General Chemistry General Medicine Catalysis Small intestine medicine.anatomical_structure Molecular recognition Orally active Biochemistry chemistry medicine Struktur aktivitats beziehungen
Zdroj:	Angewandte Chemie. 112:515-518
ISSN:	1521-3757 0044-8249
DOI:	10.1002/(sici)1521-3757(20000204)112:3<515::aid-ange515>3.0.co;2-v
Popis:	By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates of PepT1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe3c0f073702651ddcac32338dc054c https://doi.org/10.1002/(sici)1521-3757(20000204)112:3<515::aid-ange515>3.0.co Zobrazit plný text záznamu Plný text