Associations of patient characteristics, disease stage, and biopsy technique with the diagnostic quality of core needle renal biopsy specimens from dogs with suspected kidney disease
| Autor: | Christopher A. Adin, Rachel E. Cianciolo, Thomas E. Wittum, George E. Lees, L. Z. Crivellenti |
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| Přispěvatelé: | Universidade Estadual Paulista (UNESP), Franca University, The Ohio State University, Texas A and M University, North Carolina State University |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Medullary cavity Databases Factual 040301 veterinary sciences 030232 urology & nephrology Severity of Illness Index 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dogs Core Specimen Predictive Value of Tests Biopsy medicine Animals Clinical significance Dog Diseases Ultrasonography Interventional Retrospective Studies Creatinine General Veterinary medicine.diagnostic_test business.industry Biopsy Needle 04 agricultural and veterinary sciences medicine.disease Cross-Sectional Studies chemistry Renal pathology Female Kidney Diseases Radiology Renal biopsy business Kidney disease |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1943-569X |
| Popis: | Made available in DSpace on 2022-04-28T19:07:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) OBJECTIVE To identify factors affecting the diagnostic quality of core needle renal biopsy specimens from dogs with suspected kidney disease. DESIGN Cross-sectional study. ANIMALS 522 client-owned dogs with suspected kidney disease for which core needle renal biopsy specimens (n = 1,089) were submitted to the International Veterinary Renal Pathology Service for evaluation and inclusion in their database. PROCEDURES Data regarding dog signalment, clinical variables, biopsy method, needle brand and gauge, biopsy results, and other variables were extracted from the database. Variables were tested for association with 3 outcomes of light microscopic evaluation of core specimens: number of glomeruli per core specimen, obtainment of < 10 glomeruli, and presence or absence of renal medullary tissue. RESULTS Number of glomeruli per core specimen was significantly associated with needle gauge, dog age, serum creatinine concentration, and degree of proteinuria, whereas biopsy method and submitting hospital were significantly associated with the presence of renal medullary tissue in specimens. Mean numbers of glomeruli per core specimen obtained with 14-or 16-gauge needles were similar, but both were significantly greater than the mean number obtained with 18-gauge needles. Needle gauge had a similar association with the likelihood of obtaining < 10 glomeruli in a core specimen. Specimens obtained via laparotomy or laparoscopic approaches more commonly contained medullary tissue than those obtained by ultrasound-guided approaches. CONCLUSIONS AND CLINICAL RELEVANCE Overall, findings suggested that ultrasound-guided biopsy with a 16-gauge needle should maximize the diagnostic quality of renal biopsy specimens from dogs with suspected kidney disease, while avoiding potential adverse effects caused by larger needles. Department of Veterinary Clinic and Surgery São Paulo State University Department of Veterinary Clinic and Surgery Franca University Department of Veterinary Biosciences The Ohio State University Department of Veterinary Preventive Medicine The Ohio State University College of Veterinary Medicine The Ohio State University Department of Veterinary Internal Medicine College of Veterinary Medicine and Biomedical Sciences Texas A and M University Department of Clinical Sciences College of Veterinary Medicine North Carolina State University Department of Veterinary Clinic and Surgery São Paulo State University FAPESP: 2012/25515-0 |
| Databáze: | OpenAIRE |
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