D-aspartic acid in aged mouse skin and lens
| Autor: | Noriko Fujii, Itsuro Tamanoi, Hisamasa Joshima, Shiro Muraoka, Kaoru Harada, Masatoshi Kashima |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Aging
Aspartic Acid Radiation Life span Chemistry Health Toxicology and Mutagenesis Serum protein Molecular biology Mice medicine.anatomical_structure Amino acid composition D-Aspartic Acid Biochemistry Lens (anatomy) Lens Crystalline Mouse skin medicine Animals Radiology Nuclear Medicine and imaging Agar diffusion test Racemization Whole-Body Irradiation Skin |
| Zdroj: | Journal of Radiation Research. 28:117-125 |
| ISSN: | 1349-9157 0449-3060 |
| DOI: | 10.1269/jrr.28.117 |
| Popis: | D-aspartic acid (D-Asp) was detected in the skin and lens from naturally aged mice. An analysis of the amino acid composition indicated that D-Asp did not derive from collagen. An immnunological analysis using Oucterlony''s agar diffusion method also confirmed that the protein containing D-Asp was not a serum protein. The process producing D-Asp is regarded as one other than racemization because the life span of mice is not long enough to permit D-Asp by racemization. Continuous low-dose-rate gamma-irradiation (37R per day) for 102 to 112 days did not increase significantly the amount of D-Asp in skin and lens of mice. |
| Databáze: | OpenAIRE |
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