Downstream processing of virus-like particles with aqueous two-phase systems: Applications and challenges

Autor:	Hui Yi Leong, Xiao‐Qian Fu, Pau Loke Show, Shan‐Jing Yao, Dong‐Qiang Lin
Rok vydání:	2022
Předmět:	Animals Filtration and Separation Vaccines Virus-Like Particle Analytical Chemistry
Zdroj:	Journal of separation scienceREFERENCES. 45(12)
ISSN:	1615-9314
Popis:	The advancement of recombinant virus-like particle-based vaccines has attracted global attention owing to substantially safety and high efficacy in provoking a protective immunity against various chronic and infectious diseases in humans and animals. A robust, low-cost, and scalability separation and purification technology is of utmost importance in the downstream processing of recombinant virus-like particles to produce affordable and safe vaccines. Being a relatively simple, environmentally friendly, and efficient biomolecules recovery approach, aqueous two-phase systems have received great attention from researchers worldwide. This review aims to highlight the challenges and outlook in addition to the current applications of aqueous two-phase systems in downstream processing of virus-like particles. The efforts will confidently reinforce scholars' knowledge and fill in the valuable research gap in the aspect of concerning recombinant virus-like particle-based vaccines development, particularly related to the virus-like particles downstream production processes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdec3150f7a0ac57665616f47adec23 https://pubmed.ncbi.nlm.nih.gov/35191590 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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