Monoclonal antibodies to Dalargin — a synthetic analog of enkephalins
| Autor: | J.D. Bespalova, Pekelis Boris L, N.M. Ananyeva, Vinogradov Valentin A, O.V. Rokhlin, Mikhail I. Titov, V.A. Tischenko, L.Z. Yakubov |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
Enkephalin medicine.drug_class Molecular Sequence Data Immunology Monoclonal antibody Mice medicine Animals Immunology and Allergy Amino Acid Sequence Receptor Endogenous opioid chemistry.chemical_classification Mice Inbred BALB C Tetrapeptide Antibodies Monoclonal Radioimmunoassay Enkephalin Leucine-2-Alanine Molecular biology Peptide Fragments Amino acid Biochemistry chemistry Opioid Enkephalin Leucine medicine.drug |
| Zdroj: | Immunology Letters. 18:269-273 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/0165-2478(88)90173-3 |
| Popis: | Monoclonal antibodies (MABs) to a new drug Dalargin (Tyr-D-Ala-Gly-Phe-Leu-Arg) enhancing ulcer healing have been produced. Dalargin is a synthetic analog of Leu-enkephalin. With about 40 compounds tested in competition radioimmunoassay it has been shown that specificity of the MABs is directed against the N-terminal tetrapeptide of the molecule. The MABs are sensitive to amino acid substitutions in any of the positions of the fragment and have no cross-reactivity with endogenous opioids. Their further application in pharmacokinetic studies in humans and for characterization of opioid receptors is discussed. |
| Databáze: | OpenAIRE |
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