Viral Toxin NS1 Implication in Dengue Pathogenesis Making It a Pivotal Target in Development of Efficient Vaccine
| Autor: | Pascale Krejbich-Trotot, Grégorie Lebeau, Alisé Lagrave, Marjolaine Roche, Wildriss Viranaicken, Philippe Desprès, Soundary Seriacaroupin, Cédric Moutoussamy, Jean-Jacques Hoarau, Lauriane Grondin, Patrick Mavingui, Eva Ogire |
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| Přispěvatelé: | Études Pharmaco-Immunologie (EPI), Université de La Réunion (UR), Laboratoire d'Immunologie Clinique et Expérimentale de la Zone de l'Océan Indien (LICE-OI), Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Univ, Réunion |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Serotype
Immunology NS1 Plasma leakage Review viral immunopathogenesis Arbovirus Dengue fever Viral hemorrhagic fever Pathogenesis Drug Discovery medicine Pharmacology (medical) viral hemorrhagic fever viral toxin Dengue vaccine [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology Pharmacology business.industry dengue vaccine strategies medicine.disease Virology dengue Infectious Diseases arbovirus [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Medicine Viral disease business |
| Zdroj: | Vaccines Vaccines, 2021, 9 (9), ⟨10.3390/vaccines9090946⟩ Vaccines, Vol 9, Iss 946, p 946 (2021) |
| ISSN: | 2076-393X |
| DOI: | 10.3390/vaccines9090946⟩ |
| Popis: | International audience; The mosquito-borne viral disease dengue is a global public health problem causing a wide spectrum of clinical manifestations ranging from mild dengue fever to severe dengue with plasma leakage and bleeding which are often fatal. To date, there are no specific medications to treat dengue and prevent the risk of hemorrhage. Dengue is caused by one of four genetically related but antigenically distinct serotypes DENV-1–DENV-4. The growing burden of the four DENV serotypes has intensified both basic and applied research to better understand dengue physiopathology. Research has shown that the secreted soluble hexameric form of DENV nonstructural protein-1 (sNS1) plays a significant role in the pathogenesis of severe dengue. Here, we provide an overview of the current knowledge about the role of sNS1 in the immunopathogenesis of dengue disease. We discuss the potential use of sNS1 in future vaccine development and its potential to improve dengue vaccine efficiency, particularly against severe dengue illness. |
| Databáze: | OpenAIRE |
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