Hepatitis B vaccine efficacy in HCV vertical infected infants
| Autor: | Barbara Kowalik-Mikołajewska, Małgorzata Aniszewska, Maria Pokorska-Lis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Hepatitis B virus
lcsh:Immunologic diseases. Allergy Hepatitis B vaccine biology business.industry virus diseases First year of life medicine.disease_cause Virology digestive system diseases Titer Infectious Diseases Immunization Immunology medicine biology.protein Viral rna Seroconversion Antibody business lcsh:RC581-607 |
| Zdroj: | Retrovirology, Vol 5, Iss Suppl 1, p P19 (2008) |
| ISSN: | 1742-4690 |
| Popis: | Patients and methods 105 infants born to HCV infected mothers were vaccinated against hepatitis B virus (recombinant vaccine, 10 μg, 0-1-6 month schedule). The diagnosis of HCV infection in infants was based on positive viral RNA in serum by PCR (Amplicor v 2,0 Roche) on at least two separate speciments in the first year of life. HCV infection was confirmed in 18 children. 87 children who were HCV uninfected formed the control group. Anti-HBs titers were measured 3-6 months after the third dose of immunization in HCV infected children and in control group. Seroconversion was considered if anti-HBs level was ≥ 10 mIU/mL. Non-responders were tested for HBV infection by PCR. |
| Databáze: | OpenAIRE |
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