Lysophosphatidic acid signalling in development
| Autor: | Yun C. Yung, Allison Chen, Jerold Chun, Xiaoyan Sheng |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Nervous system
Biology Nervous System Receptors G-Protein-Coupled chemistry.chemical_compound Cell Movement Development at A Glance Lysophosphatidic acid medicine Animals Humans Receptor Molecular Biology Progenitor G protein-coupled receptor Reproduction Chemotaxis Cell biology medicine.anatomical_structure Signalling Biochemistry chemistry lipids (amino acids peptides and proteins) Lysophospholipids biological phenomena cell phenomena and immunity Signal transduction Signal Transduction Developmental Biology |
| Zdroj: | Development. 142:1390-1395 |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.121723 |
| Popis: | Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology. These LPA-influenced processes impact many aspects of organismal development. In particular, LPA signalling has been shown to affect fertility and reproduction, formation of the nervous system, and development of the vasculature. Here and in the accompanying poster, we review the developmentally related features of LPA signalling. |
| Databáze: | OpenAIRE |
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