Giant Congenital Melanocytic Nevi: Selected Aspects of Diagnostics and Treatment
| Autor: | Elżbieta Michalak, Klaudia Żak, Ewa Sawicka, Pawel Peczkowski, Monika Bekiesińska-Figatowska, Orest Szczygielski |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Melanosis Catecholamines Neoplasm Recurrence Clinical Research medicine Humans Nevus Neoplasm Metastasis Child Melanins Nevus Pigmented Neurocutaneous Syndromes business.industry Disease progression Infant Newborn Infant General Medicine Catecholamines urine medicine.disease Magnetic Resonance Imaging Dermatology Infant newborn Child Preschool Disease Progression Female Neoplasm Recurrence Local business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.891279 |
| Popis: | Background Treatment of giant melanocytic nevi (GMN) remains a multidisciplinary challenge. We present analysis of diagnostics, treatment, and follow-up in children with GMN to establish obligatory procedures in these patients. Material/Methods In 24 children with GMN, we analyzed: localization, main nevus diameter, satellite nevi, brain MRI, catecholamines concentrations in 24-h urine collection, surgery stages number, and histological examinations. The t test was used to compare catecholamines concentrations in patient subgroups. Results Nine children had “bathing trunk” nevus, 7 had main nevus on the back, 6 on head/neck, and 2 on neck/shoulder and neck/thorax. Brain MRI revealed neurocutaneous melanosis (NCM) in 7/24 children (29.2%), symptomatic in 1. Among urine catecholamines levels from 20 patients (33 samples), dopamine concentration was elevated in 28/33, noradrenaline in 15, adrenaline in 11, and vanillylmandelic acid in 4. In 6 NCM children, all catecholamines concentrations were higher than in patients without NCM (statistically insignificant). In all patients, histological examination of excised nevi revealed compound nevus, with neurofibromatic component in 15 and melanoma in 2. They remain without recurrence/metastases at 8- and 3-year-follow-up. There were 4/7 NCM patients with more than 1 follow-up MRI; in 1 a new melanin deposit was found and in 3 there was no progression. Conclusions Early excision with histological examination speeds the diagnosis of melanoma. Brain MRI is necessary to confirm/rule-out NCM. High urine dopamine concentration in GMN children, especially with NCM, is an unpublished finding that can indicate patients with more serious neurological disease. Treatment of GMN children should be tailored individually for each case with respect to all medical/psychological aspects. |
| Databáze: | OpenAIRE |
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