Primary Cutaneous Composite Lymphomas
| Autor: | Alexandra C. Hristov, Daniel F. Boyer, Stephanie J.T. Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Lymphoma B-Cell Skin Neoplasms Population Lymphoma T-Cell Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Immunophenotyping hemic and lymphatic diseases Cytology medicine Humans education education.field_of_study Mycosis fungoides business.industry General Medicine medicine.disease Lymphoma Medical Laboratory Technology Composite Lymphoma 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Archives of pathologylaboratory medicine. 142(11) |
| ISSN: | 1543-2165 |
| Popis: | Composite lymphomas have been defined as 2 distinct subtypes of lymphoma occurring at a single anatomic site. Composite lymphomas limited to the skin are a rare occurrence and pose a unique challenge. Many reported cases within the skin are combined B-cell and T-cell lymphomas, typically mycosis fungoides and a low-grade B-cell lymphoma. These cases are challenging to recognize because lymphoid infiltrates within the skin often include a mixed population of B cells and T cells. In particular, reactive lymphoid proliferations (pseudolymphomas), primary cutaneous low-grade B-cell lymphomas, and primary cutaneous CD4+ T-cell lymphoproliferative disorder may show nearly equal numbers of B cells and T cells. In order to exclude these possibilities, overwhelming evidence in support of each lymphoma is helpful, including abnormal architecture, cytology, and immunophenotype, as well as molecular genetic evidence of clonality. |
| Databáze: | OpenAIRE |
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