Prenatal Exposure to Lipopolysaccharide Induces PTX3 Expression and Results in Obesity in Mouse Offspring
| Autor: | Xiaohui Li, Jianzhi Zhou, Shugang Qin, Meng Gao, Xin Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Lipopolysaccharides
0301 basic medicine obesity medicine.medical_specialty MAP Kinase Signaling System Offspring Immunology Blood lipids Nerve Tissue Proteins Inflammation Carbohydrate metabolism Prenatal inflammation Mice 03 medical and health sciences Pregnancy Internal medicine Animals Immunology and Allergy Medicine PTX3 biology business.industry lipopolysaccharide C-reactive protein medicine.disease Obesity C-Reactive Protein 030104 developmental biology Endocrinology Prenatal Exposure Delayed Effects biology.protein Female Original Article medicine.symptom business |
| Zdroj: | Inflammation |
| ISSN: | 1573-2576 0360-3997 |
| Popis: | This study tested the hypothesis whether inflammation will directly lead to obesity. This study was designed to investigate the relationship between inflammation and obesity by intraperitoneally injecting pregnant mice with lipopolysaccharide (LPS) (75 μg kg−1). The results showed that inflammation during pregnancy could lead to a significant increase in the levels of the inflammatory factor PTX3. The offspring of the LPS-treated mice displayed abnormal levels of fat development, blood lipids, and glucose metabolism, and fat differentiation markers were significantly increased. Our study also confirmed that PTX3 can increase the susceptibility to obesity by regulating the expression of adipogenic markers; this regulatory role of PTX3 is most likely caused by MAPK pathway hyperactivation. Our study is the first to find strong evidence of inflammation as a cause of obesity. We determined that PTX3 was an important moderator of obesity, and we elucidated its mechanism, thus providing new targets and theories for obesity therapy. Moreover, our study provides new ideas and directions for the early intervention of anti-inflammation in pregnancy. |
| Databáze: | OpenAIRE |
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