Granulocyte colony-stimulating factor production by adult T-cell leukaemia cells
| Autor: | Chuwa Tei, Toshimasa Kukita, Hiroshi Fujiwara, Tadashi Matsumoto, Shiroh Hidaka, Yuichi Tokito, Atsuo Ozaki, Hideo Ohtsubo, Katsuya Yamaguchi, Kakushi Matsushita, Kosei Arimura, Naomichi Arima |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Leukemia T-Cell Neutropenia medicine.medical_treatment T-Lymphocytes Granulocyte Leukocyte Count hemic and lymphatic diseases White blood cell Granulocyte Colony-Stimulating Factor medicine Humans Cells Cultured Aged biology Hematology Middle Aged Neutrophilia Granulocyte colony-stimulating factor Autocrine Communication Blotting Southern medicine.anatomical_structure Cytokine Immunology Absolute neutrophil count biology.protein Female medicine.symptom Antibody Cell Division Granulocyte colony-stimulating factor production |
| Zdroj: | British journal of haematology. 111(1) |
| ISSN: | 0007-1048 |
| Popis: | We previously demonstrated that, in about 30% of primary adult T-cell leukaemia (ATL) cases, the leukaemic cells proliferated in response to granulocyte colony-stimulating factor (G-CSF). In the present report, we describe five patients with the acute leukaemia type of ATL who showed marked neutrophilia and elevated serum G-CSF concentrations in the absence of infection. We further examined two of these patients for detailed clinical features and cellular characteristics of the tumour cells. The white blood cell counts of both patients were 62 × 109/l, consisting of approximately 90% neutrophils and 10% ATL cells. Serum concentrations of G-CSF in the two patients were 138 pg/ml and 93 pg/ml. The G-CSF concentrations in supernatants of short-term cultures of the patients' peripheral blood T-cells were 2·5 pg/ml and 13 pg/ml respectively. Immunostaining with anti-G-CSF antibody demonstrated G-CSF production by primary ATL cells in both cases. The neutrophil count fluctuated simultaneously with activity of ATL. Primary ATL cells from one patient were shown to proliferate in response to G-CSF in vitro. These results suggest autocrine growth stimulation of primary ATL cells in a subgroup of patients. |
| Databáze: | OpenAIRE |
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