Synthesis and biological evaluation of novel hygromycin A antibacterial agents
| Autor: | Kevin Daniel Freeman-Cook, Katherine E. Brighty, Phuong Le, Michael Scott Visser, Gary J. Martinelli, Sarah K. Wade, Steven J. Brickner, Dianna E. Moore, Rhonda Monahan, Kyle T. Blair |
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| Rok vydání: | 2010 |
| Předmět: |
Chemistry
Organic Chemistry Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Alkylation Biochemistry Combinatorial chemistry Anti-Bacterial Agents Aminocyclitol chemistry.chemical_compound Cinnamates Drug Discovery Molecular Medicine Hygromycin B Antibacterial activity Molecular Biology Hygromycin A Biological evaluation |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 20:6730-6734 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2010.08.139 |
| Popis: | Novel hygromycin A derivatives bearing a variety of functionalized aminocyclitol moieties have been synthesized in an effort to increase the antibacterial activity and drug-like properties of this class of agents. A systematic study of the effect of alkylation and removal of the hydroxyls of the aminocyclitol directed us to a series of alkylated aminocyclitol derivatives with improved Gram-positive activity. |
| Databáze: | OpenAIRE |
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