Sex differences in insulin and glucagon responses for glucose homeostasis in young healthy Japanese adults
Autor: | Junya Akeshima, Yoshitaka Mori, Atsushi Kawakami, Aya Nozaki, Takao Ando, Ai Haraguchi, Ichiro Horie, Norio Abiru, Tomoe Nakao, Ayako Ito, Mami Eto, Ayaka Sako, Satoru Akazawa, Yomi Nakashima, Tetsuro Niri |
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Rok vydání: | 2018 |
Předmět: |
Adult
Blood Glucose Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Short Report Glucagon KIT 030209 endocrinology & metabolism Glucagon Young Adult 03 medical and health sciences 0302 clinical medicine Asian People Japan Internal medicine Diabetes mellitus Insulin Secretion Internal Medicine medicine Homeostasis Humans Insulin Glucose homeostasis Oral glucose tolerance Young adult Insulin secretion Sex Characteristics business.industry Articles General Medicine Glucose Tolerance Test medicine.disease Clinical Science and Care 030104 developmental biology Endocrinology Female Sex business |
Zdroj: | Journal of Diabetes Investigation |
ISSN: | 2040-1116 |
Popis: | It has been reported that glucose responses during the oral glucose tolerance test differ between healthy women and men. However, it remains unknown what factors contribute to these differences between the sexes. The present study analyzed the insulin and glucagon responses during the oral glucose tolerance test in 25 female and 38 male healthy young adults aged 22–30 years. The plasma glucose levels at 120 min were significantly higher in women than men. Insulin secretion was significantly greater at 30, 90 and 120 min from baseline in women than men. Glucagon suppression was greater at 30 and 120 min from baseline in men than women when determined by a sandwich enzyme‐linked immunosorbent assay glucagon kit. These results suggest that the differences in glucose responses during the oral glucose tolerance test are mediated by the difference between the sexes in bi‐hormonal responses in healthy individuals. |
Databáze: | OpenAIRE |
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