Factors Associated With Disease Recurrence in Breast Cancer Patients With Negative Sentinel Lymph Node Biopsy
| Autor: | Javier Briceño-Delgado, Marina Álvarez-Benito, Irene Gomez-Luque, Juan Ruiz-Rabelo, Manuela Torres-Lorite, Nélida Díaz-Jiménez, Pilar Rioja-Torres, Elena Navarro-Rodríguez, Rubén Ciria-Bru, Guillermo Bascuñana-Estudillo |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Lymphovascular invasion Sentinel lymph node Breast Neoplasms 030230 surgery Disease-Free Survival 03 medical and health sciences Young Adult 0302 clinical medicine Breast cancer Risk Factors Internal medicine Biopsy Adjuvant therapy Medicine Humans Prospective Studies Survival rate Aged Neoplasm Staging Aged 80 and over medicine.diagnostic_test business.industry Sentinel Lymph Node Biopsy Hazard ratio Sentinel node Middle Aged medicine.disease Prognosis Combined Modality Therapy Survival Rate 030220 oncology & carcinogenesis Lymphatic Metastasis Axilla Female Neoplasm Recurrence Local Sentinel Lymph Node business Follow-Up Studies |
| Zdroj: | Clinical breast cancer. 16(6) |
| ISSN: | 1938-0666 |
| Popis: | Introduction The objective of our study was to assess recurrence after negative sentinel lymph node biopsy (SLNB) and to determine the risk factors related to local and distant recurrence in this group of patients. Materials and Methods We conducted a prospective observational study from 2006 to 2011. It included 607 patients with early-stage breast cancer and negative SLNB with a 5-year follow-up period. Results The disease-free survival rate was 98.5% and 96.5% at 2 and 5 years, respectively. Multivariate analysis identified the following prognostic factors for disease recurrence: tumor necrosis (hazard ratio [HR], 4.89; 95% confidence interval [CI], 1.61-14.89; P = .005), lymphovascular invasion (HR, 3.46; 95% CI, 1.14-10.55; P = .029), T2 tumor size (HR, 4.35; 95% CI, 1.40-13.52; P = .011), and moderate to severe lymphoplasmacytic stromal infiltration (HR, 3.06; 95% CI, 1.18-7.96; P = .022). Conclusion Recurrence in patients with negative SLNB was satisfactorily low. Nevertheless, determining the prognostic factors related to a greater recurrence rate could help identify high-risk patients and influence systemic adjuvant therapy. |
| Databáze: | OpenAIRE |
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