Circadian genesPer1andPer2increase radiosensitivity of gliomain vivo
| Autor: | Hao Shaocai, Xia Hechun, Li Guangxing, Niu Zhanfeng, Li Yanhui, Fei Zhou |
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| Rok vydání: | 2015 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Biology Radiation Tolerance Rats Sprague-Dawley In vivo Internal medicine Glioma medicine Animals RNA Messenger Radiosensitivity Circadian rhythm Brain Neoplasms Per2 Per1 Period Circadian Proteins medicine.disease Circadian Rhythm Rats PER2 Endocrinology Oncology Apoptosis radiotherapeutic sensitivity Cancer research Research Paper PER1 |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.3179 |
| Popis: | Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis. |
| Databáze: | OpenAIRE |
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