Hepatotoxicity of acetaldehyde in rats
| Autor: | Maged Younes, T. Urch, R. Pentz, Otfried Strubelt, H. Breining |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Toxic hepatitis L-Iditol 2-Dehydrogenase Hepatotoxic effect Aldehyde dehydrogenase Acetaldehyde Pharmacology Toxicology chemistry.chemical_compound Reference Values medicine Animals Aspartate Aminotransferases chemistry.chemical_classification Ethanol biology Chemistry Liver cell Alanine Transaminase Rats Inbred Strains General Medicine Rats Enzyme Liver Biochemistry Disulfiram biology.protein medicine.symptom medicine.drug |
| Zdroj: | Toxicology Letters. 39:77-84 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/0378-4274(87)90259-1 |
| Popis: | The ability of acetaldehyde to initiate hepatotoxicity as evidenced by enzyme leakage, hepatic fat accumulation and histological alterations was studied in rats. Neither oral nor intraperitoneal treatment with acetaldehyde had any hepatotoxic effect, even following aldehyde dehydrogenase inhibition by disulfiram. This is probably due to the inability of exogenously added acetaldehyde to penetrate liver cell membranes. In contrast, acetaldehyde derived metabolically from ethanol was capable of inducing moderate hepatotoxicity when it accumulated upon pretreatment with disulfiram. Acetaldehyde may thus be partly responsible for alcohol-induced liver damage. |
| Databáze: | OpenAIRE |
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