Uterine NK cell development, migration and function
| Autor: | Angela Gismondi, Claudia Carlino, Angela Santoni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Chemokine
integrin Cellular differentiation chemokines uterine nk cell Models Biological menstrual cycle Chemokine receptor Interleukin 21 Cell Movement cytokines pregnancy Animals Humans Progenitor cell Lymphokine-activated killer cell biology Uterus Obstetrics and Gynecology Cell Differentiation Natural killer T cell Cell biology Killer Cells Natural Reproductive Medicine embryonic structures Immunology biology.protein Interleukin 12 Female Developmental Biology |
| Popis: | Uterine natural killer (uNK) cells represent the predominant lymphocytes in the uterus during early pregnancy and in the secretory phase of the menstrual cycle. They are CD56(high)CD16(-) and have low cytotoxicity, but constitutively secrete a number of cytokines, chemokines and angiogenic molecules. uNK cells differ from CD56(high) blood NK cells in several ways, including the killer cell immunoglobulin-like receptor repertoire and expression of some genes induced by hormone environment. uNK cells may arise by in-utero proliferation and differentiation of NK cell progenitors under the control of the sex steroid hormones and/or cytokines, such as interleukin-15, and/or be recruited from CD56(+) blood NK cells that would undergo tissue-specific differentiation in the uterine microenvironment. There is evidence showing that uNK cells display a different pattern of chemokine receptors and adhesion molecules, thus leading to a different migratory response. It has not yet been fully defined which uNK cell function(s) are critical for successful pregnancy. The close encirclement of spiral arteries by NK cells, together with their ability to produce angiogenic factors, suggests that they might influence mucosal vascularization. Their proximity to the extravillous trophoblast supports the idea that uNK cells could recognize these cells as fetal, and regulate their invasion during placentation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|