Impact of resection margin status after nephron-sparing surgery for renal cell carcinoma
| Autor: | Stefan Zastrow, Oliver W. Hakenberg, Vladimir Novotny, Navid Berdjis, S. Oehlschläger, Manfred P. Wirth |
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| Rok vydání: | 2006 |
| Předmět: |
Nephrology
medicine.medical_specialty Surgical margin Urology Nephrectomy Renal cell carcinoma Internal medicine medicine Carcinoma Humans Neoplasm Metastasis Carcinoma Renal Cell Neoplasm Staging Retrospective Studies Frozen section procedure business.industry Nephrons medicine.disease Kidney Neoplasms Surgery Treatment Outcome Resection margin Disease Progression Radiology Neoplasm Recurrence Local business Kidney cancer Kidney disease Follow-Up Studies |
| Zdroj: | BJU international. 97(6) |
| ISSN: | 1464-4096 |
| Popis: | OBJECTIVE To evaluate whether the negative-margin width after nephron-sparing surgery for renal cell carcinoma (RCC) is associated with tumour recurrence. PATIENTS AND METHODS In all, 121 patients had nephron-sparing surgery for non-metastatic RCC for elective (85 cases) and imperative (36 cases) indications. Intraoperative frozen sections were routinely obtained and revealed negative margins in all patients. The tumour size and the shortest distance of normal parenchyma around the tumour were assessed. RESULTS After a mean (range) follow-up of 49.3 (12-113) months, six patients had disease progression (three with local recurrence, two of whom also had distant metastases and pure metastatic disease in three). The mean (range) width of the negative margins was 0.56 (0.1–2.3) cm. The width of the resection margin did not correlate with disease progression, while tumour size was a strong predictor of progression (P |
| Databáze: | OpenAIRE |
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