Kinetics of an orally absorbed aldose reductase inhibitor, sorbinil
| Autor: | George Foulds, Mark M O'Brien, Kenneth H. Gabbay, Joseph R Bianchine |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Pharmacology
Volume of distribution Oral dose Chemistry Kinetics Imidazoles Administration Oral Urine Imidazolidines Aldose reductase inhibitor chemistry.chemical_compound Aldehyde Reductase medicine Humans Pharmacology (medical) Sorbinil Terminal Half Life Sugar Alcohol Dehydrogenases Clearance medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics. 30:693-700 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.1981.222 |
| Popis: | Kinetics of sorbinil, an orally absorbed aldose reductase inhibitor, were examined in man. Peak plasma concentrations were 0.95 μg/ml after a single 50-mg oral dose and 3.6 μg/ml after a 250-mg dose. The apparent volume of distribution was 840 ml/kg. Elimination from plasma was slow with a terminal half life between 6 and 24 hr after dose of 34 to 52 hr and a renal clearance of 6.0 ml/min/1.73 m2. Administration of 50 mg/day for 5 claws induced a mean peak serum concentration of 1.9 μg/ml. A dose of 250 mg/day for 10 days induced a peak serum concentration of 10.6 μg/ml. A mean of one-third of the dose was ultimately recovered unchanged in urine. Sorbinil kinetics make it suitable for once-a-day dosing. Clinical Pharmacology and Therapeutics (1981) 30, 693–700; doi:10.1038/clpt.1981.222 |
| Databáze: | OpenAIRE |
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