Cooperation of selection and meiotic mechanisms in the production of imbalances in reciprocal translocations
| Autor: | M. A. Mermet, T. Faraut, Jacques Demongeot, Olivier Cohen |
|---|---|
| Přispěvatelé: | ProdInra, Migration, Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées |
| Rok vydání: | 2000 |
| Předmět: |
Male
Aging Heterozygote Offspring [SDV]Life Sciences [q-bio] CHROMOSOME ABNORMALITIES Aneuploidy Trisomy Chromosomal translocation Biology Translocation Genetic 03 medical and health sciences 0302 clinical medicine Gene Frequency Meiosis Chromosome Segregation Genetics medicine Humans Crossing Over Genetic Selection Genetic Molecular Biology ComputingMilieux_MISCELLANEOUS Genetics (clinical) 030304 developmental biology Sex Characteristics 0303 health sciences 030219 obstetrics & reproductive medicine Infant Newborn Chromosome MEIOSIS medicine.disease Spermatozoa Sperm [SDV] Life Sciences [q-bio] medicine.anatomical_structure Linear Models Gamete Female Maternal Age |
| Zdroj: | Cytogenetics and Cell Genetics Cytogenetics and Cell Genetics, S Karger AG, 2000, 88, pp.15-21 |
| ISSN: | 1424-859X 1424-8581 0301-0171 1421-9816 |
| Popis: | We have used data from chromosomally unbalanced offspring observed at birth, as well as data from sperm chromosome analysis, to study the meiotic segregation of reciprocal translocations. Using data from a total of 1,597 unbalanced children, we have observed an excess in maternal origin for all modes of imbalance. This excess is particularly marked for the 3:1 unbalanced mode, for which we have also observed a maternal age effect, indicating a close relationship with autosomal trisomies. In addition, a statistical analysis of data from 34 different published studies using sperm chromosome analysis has demonstrated that factors which, for reasons of viability, produce a predisposition for a particular mode of imbalance at birth also appear to favor meiotic production of this type of imbalance. Thus the production of unbalanced gametes of a particular type is influenced by the size of the imbalance. |
| Databáze: | OpenAIRE |
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